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Olprinone Hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Olprinone Hydrochloride图片
CAS NO:119615-63-3
包装与价格:
包装价格(元)
10 mM * 1 mL in Water电议
10mg电议
50mg电议
100mg电议
200mg电议
500mg电议

产品名称
盐酸奥普力农
Loprinone Hydrochloride
产品介绍
Olprinone (Loprinone) Hydrochloride 是一种有效的磷酸二酯酶(PDE) 3抑制剂,对 PDE1,PDE2,PDE3,PDE4 的IC50分别为 150、100、0.35 和 14 μM。Olprinone Hydrochloride 因其正性肌力和血管扩张作用而被用于心力衰竭的研究。Olprinone Hydrochloride 具有抗炎活性。
生物活性

Olprinone (Loprinone) Hydrochloride is a potentphosphodiesterase (PDE)3inhibitor, withIC50s of 150, 100, 0.35 and 14 μM forPDE1,PDE2,PDE3andPDE4, respectively. Olprinone Hydrochloride is used for the research of heart failure due to its positive inotropic and vasodilative effects. Anti-inflammatory activity[1][2].

体内研究
(In Vivo)

Olprinone (Loprinone) Hydrochloride (0.2 mg/kg; i.p.) modulates the inflammation associated with myocardial ischemia-reperfusion injury in rats[1].

Animal Model:Male adult Wistar rats (250-300 g) (ischemia–reperfusion rats)[1]
Dosage:0.2 mg/kg
Administration:I.p. (administered 15 min after ischemia)
Result:Significantly reduced the: (1) histological evidence of myocardial injury, (2) pro-inflammatory cytokines: tumor necrosis factor-α (TNF-α) and Interleukin-1β (IL-1β), (3) adhesion molecules: Inter-Cellular Adhesion Molecule 1 (ICAM-1) and P-Selectin, (4) nitrotyrosine formation, (5) nuclear factor kappa-B (NF-κB) expression, (6) Poly (ADP-ribose) (PAR) formation, and (7) apoptosis (Bax, Bcl-2, Fas-L and terminal deoxynucleotidyl transferase-mediated UTP end labeling (TUNEL).
分子量

286.72

性状

Solid

Formula

C14H11ClN4O

CAS 号

119615-63-3

中文名称

盐酸奥普力农

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O : ≥ 7.69 mg/mL(26.82 mM)

*"≥" means soluble, but saturation unknown.

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM3.4877 mL17.4386 mL34.8772 mL
5 mM0.6975 mL3.4877 mL6.9754 mL
10 mM0.3488 mL1.7439 mL3.4877 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。