PF-CBP1 is a highly selective inhibitor of the CREB binding protein bromodomain^[1].

PF-CBP1 modulates key inflammatory genes in primary macrophages. PF-CBP1 downregulates RGS4 in neurons, a target linked to Parkinson's disease. PF-CBP1 is 139-fold selective over BRD4 in the biochemical assays and >105-fold selective by ITC. F-CBP1 is also a potent inhibitor of EP300 (a result observed for other CBP inhibitors^[1].

488.62

C₂₉H₃₆N₄O₃

1962928-21-7

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