CAS NO: | 2416937-01-2 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | S65487 (VOB560) sulfate, a potent and selectiveBcl-2inhibitor, is a prodrug of S55746. S65487 sulfate is also active onBCL-2mutations, such as G101V and D103Y. S65487 sulfate has poor affinity withMCL-1,BFL-1andBCL-XL. S65487 sulfate inducesapoptosisand has anticaner activities[1][2]. | ||||||||||||||||
体外研究 (In Vitro) | S65487 binds to the BH3 hydrophobic groove of BCL-2. S65487 induces apoptosis in a panel of hematological cancer cell lines and inhibits cell proliferation with IC50s in the low nM range[1]. | ||||||||||||||||
体内研究 (In Vivo) | S65487 induces complete regression in BCL-2-dependent RS4;11 tumors in vivo after a single IV (intravenous) administration. Strong and persistent tumor regression in xenograft models of lymphoid malignancies in mouse and rat are observed at well tolerated doses following weekly IV administration of S65487 in combination with the MCL-1-specific inhibitor, S64315/MIK665[1]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 815.33 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C41H43ClN6O8S | ||||||||||||||||
CAS 号 | 2416937-01-2 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 135 mg/mL(165.58 mM;Need ultrasonic) H2O : 1.25 mg/mL(1.53 mM;ultrasonic and warming and heat to 60℃) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
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