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CXL-1020
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CXL-1020图片
CAS NO:950834-06-7
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
CXL-1020 是一种基于羟胺基的硝基 (HNO) 供体。CXL-1020 改善舒张异常大鼠的心肌收缩性/舒张性和 Ca2+循环。CXL-1020 在犬模型中诱导血管舒张,改善心脏功能。CXL-1020 已被用于研究收缩期心力衰竭和稳定期心力衰竭。
生物活性

CXL-1020 is a hydroxylamine-based nitroxyl (HNO) donor. CXL-1020 improves cardiac inotropy/lusitropy and Ca2+cycling in rats with abnormal relaxation. CXL-1020 induces vasorelaxation and improves cardiac function in canine models. CXL-1020 has been used to research systolic heart failure and stable heart failure[1].

IC50& Target[1]

L-type calcium channel

 

体内研究
(In Vivo)

CXL-1020 (100 μg/kg/min; infusion for 30 min) improves hemodynamics and cardiac function, and enhances both diastolic and systolic performance in mice[1].
CXL-1020 (3 and 10 mg/kg/min; 4-hour intravenous infusion) improves left ventricular systolic and diastolic function in dogs with advanced heart failure[2].

Animal Model:Adult male Sprague-Dawley rats (250-350 g; induced cardiac dysfunction by isoproterenol)[1]
Dosage:100 μg/kg/min
Administration:For 30 min
Result:Improved hemodynamics and cardiac function in normal rats, and enhanced both diastolic and systolic performance in cardiac dysfunction mice.
Animal Model:Dogs (coronary microembolization-induced heart failure)[2]3 and 10 mg/kg/min
Dosage:3 and 10 mg/kg/min
Administration:4-hour intravenous infusion
Result:Decreased systolic aortic pressure (AoP) modestly; significantly increased EF and deceleration time of early mitral inflow velocity (DT) and significantly lowered left ventricular (LV) end-systolic volume (ESV), LV end-diastolic pressure (EDP) and end-diastolic wall stress (EDWS) in a dose-dependent manner.
Clinical Trial
分子量

251.28

Formula

C7H9NO5S2

CAS 号

950834-06-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.