CAS NO: | 1821143-79-6 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | DMU2105 is a potent and specificCYP1B1inhibitor, withIC50sof 10 nM and 742 nM for CYP1B1 and CYP1A1, respectively. | ||||||||||||||||
IC50& Target |
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体外研究 (In Vitro) | DMU2105 (Compound 7k) shows 74 and 120-fold selectivity for CYP1B1 over CYP1A1 and CYP1A2. In the presence of DMU2105 however, the EC50goes down to 1 μM indicating that the cells have suffered from toxicity which may have been mediated by CYP1B1 inhibition. Un-transfected cells (HEK293: pcDNA3.1), when treated with cisplatin and DMU2105 (10×IC50) do not show any perceptible decrease of cisplatin EC50(8.5 μM ± 0.9)[1]. | ||||||||||||||||
分子量 | 259.30 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C18H13NO | ||||||||||||||||
CAS 号 | 1821143-79-6 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 33.33 mg/mL(128.54 mM;ultrasonic and warming and heat to 60℃) 配制储备液
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以下溶剂前显示的百
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