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Yohimbine Hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Yohimbine Hydrochloride图片
CAS NO:65-19-0
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
20mg电议

产品介绍
Yohimbine Hydrochloride 是一种 α2-肾上腺素受体拮抗剂,可阻断突触前和突触后的 α-2 肾上腺素受体并导致去甲肾上腺素和多巴胺的释放增加。
Cas No.65-19-0
别名盐酸育亨宾;育酚;育亨宾盐酸盐;柯楠质盐酸盐;萝芙根 (皮) 碱盐酸盐;盐酸萝芙根 (皮) 碱
化学名methyl (1S,15R,18S,19R,20S)-18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate;hydrochloride
Canonical SMILESCOC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O.Cl
分子式C21H26N2O3.HCl
分子量390.9
溶解度≥ 8.9mg/mL in DMSO
储存条件Store at 4°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Yohimbine Hydrochloride is an alpha 2-adrenoreceptor antagonist, blocking the pre- and postsynaptic alpha-2 adrenoreceptors and causing an increased release of noradrenaline and dopamine.

Yohimbine Hydrochloride (0.2 mg/kg, i.p.) was administered to rats 1h before the stress session daily for 14 consecutive days and its effect was assessed. Results of this section revealed that, immersion of rats in cold water significantly decreased sexual arousal and motivation as indicated by increased latencies and intervals. Decreased copulatory activity was confirmed by decreased testosterone, luteinizing hormone (LH) and follicle-stimulating-hormone (FSH) levels as well as decreased cholesterol content in rat testes. Treatment with yohimbine significantly increased the sexual arousal and potency and corrected the effects induced by stress on the mating behavior of male rats[1].

References:
[1]. Saad MA, et al. Potential effects of yohimbine and sildenafil on erectile dysfunction in rats.
[2]. Docherty JR. Yohimbine antagonises α1A- and α1D-adrenoceptor mediated components in addition to the α2A-adrenoceptor component to pressor responses in the pithed rat. Eur J Pharmacol. 2012 Mar 15;679(1-3):90-4.
[3]. Lahiri P, et al. Platelet responsiveness to yohimbine hydrochloride and MRS2179 in the context of the interaction between collagen and epinephrine in acute coronary syndrome. Blood Cells Mol Dis. 2009 Jul-Aug;43(1):105-10.