CAS NO: | 2306193-61-1 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | VZ185 is a potent, fast, and selectivevon Hippel-Lindaubased dual degrader probe ofBRD9andBRD7withDC50s of 4.5 and 1.8 nM, respectively. VZ185 is cytotoxic in EOL-1 and A-402 cells, with EC50s of 3 nM and 40 nM, respectively[1]. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | Degradation analysis in a panel of other human cancer cell lines (EOL-1, A-204) confirms the potency of VZ185 (DC50between 2 and 8 nM for BRD9). In vitro PK data further showed high stabilities of VZ185 in both plasma and microsomes from both human and mouse species, as well as high aqueous kinetic solubility (up to ~100 μM)[1]. | ||||||||||||||||
分子量 | 995.21 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C53H67FN8O8S | ||||||||||||||||
CAS 号 | 2306193-61-1 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 200 mg/mL(200.96 mM;Need ultrasonic) 配制储备液
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