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TP-238
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TP-238图片
CAS NO:2415263-04-4
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
TP-238 是一种有效的选择性CECR2/BPTF双探针,IC50值分别为 30 nM 和 350 nM。TP-238 还抑制BRD9pIC50为 5.9,对其他 338 激酶的活性较低。
生物活性

TP-238 is a potent and selective dualCECR2/BPTFprobe withIC50values of 30 nM and 350 nM, respectively. TP-238 also inhibitsBRD9with apIC50of 5.9 and is less active against other 338 kinases[1][2].

IC50& Target

CECR2

7.5 (pIC50)

BRD9

5.9 (pIC50)

CECR2

30 nM (IC50)

CECR2

10 nM (Kd)

BPTF

6.5 (pIC50)

BPTF

350 nM (IC50)

BPTF

120 nM (Kd)

体外研究
(In Vitro)

TP-238 has on target biochemical activity of 10-30 nM with CECR2 and 100-350 nM with BPTF. TP-238 displays potency for both CECR2 (pIC50 of 7.5) and BPTF (pIC50 of 6.5) in an Alpha screen assay. Isothermal titration calorimetry (ITC) shows TP-238 with a Kd of 10 nM for CECR2 and 120 nM for BPTF[1][2].

分子量

458.58

Formula

C22H30N6O3S

CAS 号

2415263-04-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.