PDE10A-IN-2 hydrochloride

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议

产品介绍

PDE10A-IN-2 hydrochloride 是一种有效的，高选择性，具有口服活性的磷酸二酯酶 10A (PDE10A) 的抑制剂，IC₅₀为 2.8 nM。PDE10A-IN-2 hydrochloride 对其他 PDE 亚型显示出大于 3500 倍的选择性，并可用于肺动脉高压 (PAH) 的研究。

生物活性

PDE10A-IN-2 hydrochloride is a potent, highly selective and orally activephosphodiesterase10A (PDE10A)inhibitor with anIC₅₀of 2.8 nM. PDE10A-IN-2 hydrochloride shows selectivity of >3500-fold against other PDE subtypes. PDE10A-IN-2 hydrochloride can be used for pulmonary arterial hypertension (PAH) research^[1].

IC₅₀& Target^[1]

PDE10A

2.8 nM (IC₅₀)

体内研究
(In Vivo)

PDE10A-IN-2 hydrochloride (compound 14 3HCL; 2.5 mg/kg; oral administration; daily; for 3 weeks) treatment decreases the typical symptoms of PAH in rats^[1].
In Sprague-Dawley rats, the pharmacokinetic study of PDE10A-IN-2 hydrochloride (compound 14 3HCL; 10 mg/kg) shows the oral bioavailability up to ~50%, and the T_1/2is 5.2 hours (p.o.), and the C_maxis 272 ng/mL^[1].

Animal Model:	Wister rats (6 weeks, 160-180 g) injected with Monocrotaline^[1]
Dosage:	2.5 mg/kg
Administration:	Oral administration; daily; for 3 weeks
Result:	Decreased symptoms of the pulmonary arterial hypertension (PAH) rats.

分子量

627.05

性状

Solid

Formula

C₃₃H₃₈Cl₃N₅O

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

DMSO : 100 mg/mL(159.48 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	1.5948 mL	7.9738 mL	15.9477 mL
5 mM	0.3190 mL	1.5948 mL	3.1895 mL
10 mM	0.1595 mL	0.7974 mL	1.5948 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。