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5-Aminovaleric acid hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
5-Aminovaleric acid hydrochloride图片
CAS NO:660-88-8
包装与价格:
包装价格(元)
5g电议
25g电议

产品介绍
5-氨基戊酸盐酸盐被认为是 γ-氨基丁酸 (GABA) 的亚甲基同系物,并作为弱 GABA 激动剂发挥作用。
Cas No.660-88-8
别名5-氨基戊酸
化学名5-aminopentanoic acid
Canonical SMILESO=C(O)CCCCN
分子式C5H11NO2
分子量117.15
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

5-Aminovaleric acid has been identified as an important five-carbon platform chemical, which can be used for the synthesis of polymers and other chemicals of industrial interest as well.

In vitro: 5-Aminovaleric acid, a GABA analog, was reported to be able to inhibit GABA uptake, inactivate GABA aminotransferase, and could also both agonize and antagonize GABAb receptors. In addition, 5-aminovaleric acid has been found to be able to increase glutamine concentrations, thus possibly compensating for the decreased concentration of brain glutamine [1].

In vivo: Animal study found that 5-aminovaleric acid-treated rats showed a 3.5-fold reduction in the number of seizures than PBS-treated rats. In addition, both groups showed similar seizure frequency (~1 seizure/day). However, the fraction of the most severe type of seizures increased over time in the PBS treated group, but not in the 5-aminovaleric acid treated group. Moreover, 5-aminovaleric acid treated rats experienced a 2.3- and 2.6-fold lower fraction of stage 4 and 5 seizures than PBS-treated rats [1].

Clinical trial: Aminocaproic acid has been approved by FDA for the treatment of acute bleeding caused by elevated fibrinolytic activity. It has also been used for the prevention of recurrent hemorrhage in patients with traumatic hyphema [https://en.wikipedia.org/wiki/Aminocaproic_acid].

Reference:
[1] Dhaher R,Damisah EC,Wang H,Gruenbaum SE,Ong C,Zaveri HP,Gruenbaum BF,Eid T.  5-aminovaleric acid suppresses the development of severe seizures in the methionine sulfoximine model of mesial temporal lobe epilepsy. Neurobiol Dis.2014 Jul;67:18-23.