Nrf2/HO-1-IN-1 is a potentNrf2/HO-1pathway inhibitor, with anIC₅₀value of 0.38 μM forNO. Nrf2/HO-1-IN-1 can significantly reduce the level ofROSin cells. Nrf2/HO-1-IN-1 can be used for researching anti-inflammatory^[1].

IC₅₀: 0.38 μM (NO)^[1]

Nrf2/HO-1-IN-1 (compound 23d) (0.25, 0.5, 1 and 2 μM; 3 hours) can reduce ROS production in RAW264.7 cells stimulated with LPS (0.5 μg/mL LPS stimulates for 12 hours)^[1].
Nrf2/HO-1-IN-1 (0.25, 0.5, 1 and 2 μM; 3 hours) significantly increases the expression of Nrf2 and HO-1 in LPS-stimulated RAW264.7 cells in a dose-dependent manner, and promoting LPS-induced Nrf2 nuclear translocation^[1]

746.82

C₃₆H₄₆N₂O₁₃S

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.