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Tau-aggregation and neuroinflammation-IN-1
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Tau-aggregation and neuroinflammation-IN-1图片
CAS NO:2175953-98-5
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Tau-aggregation and neuroinflammation-IN-1 是一种有效的 Tau 蛋白聚集体和神经炎症抑制剂。Tau-aggregation and neuroinflammation-IN-1 对 AcPHF6 和全长 tau 蛋白聚集体表现出显著的抑制活性。Tau-aggregation and neuroinflammation-IN-1 对 LSP 刺激的 BV2 细胞具有低细胞毒性并能减少NO释放。Tau-aggregation and neuroinflammation-IN-1 可逆转冈田酸诱导的大鼠记忆障碍。
生物活性

Tau-aggregation and neuroinflammation-IN-1 is a potenttau-aggregationandneuroinflammationinhibitor. Tau-aggregation and neuroinflammation-IN-1 exhibits remarkable inhibitory activities against AcPHF6 and full-length tau aggregation. Tau-aggregation and neuroinflammation-IN-1 has a low cytotoxicity and reducedNOrelease in LPS-stimulated BV2 cells. Tau-aggregation and neuroinflammation-IN-1 can reverse okadaic acid-induced memory impairment in rats[1].

IC50& Target

AcPHF6, tau-aggregation, NO[1]

体外研究
(In Vitro)

Tau-aggregation and neuroinflammation-IN-1 (compound 30) (0-40 μM) reduces the survival of SH-SY5Y cells at 30 μM, and exerts no significant hepatotoxicity in LO2 cells at high concentrations, also exerts no effect on BV2 cell viability at 20 μM[1].
Tau-aggregation and neuroinflammation-IN-1 (2.5, 5 and 10 μM; 24 hours) retains the anti-inflammatory activity of sodium usnate and inhibits NO release rate by 41% in LPS-stimulated BV2 cells at 10 μM[1].

Cell Cytotoxicity Assay

Cell Line:SH-SY5Y, LO2 and BV-2 cells[1]
Concentration:0, 10, 20, 30 and 40 μM
Incubation Time:24 hours
Result:Reduced the survival of SH-SY5Y cells at 30 μM, and exerted no significant hepatotoxicity in LO2 cells even at high concentrations (up to 40 μM), also exerted no effect on BV2 cell viability at 20 μM.
体内研究
(In Vivo)

Tau-aggregation and neuroinflammation-IN-1 (5 and 10 mg/kg; for 14 days) leads to a substantial improvement of the conventional reference spatial memory and cognitive abilities of OA-induced rats[1].

Animal Model:Male SD rats (250-270 g; OA was microinjected into the right dorsal hippocampus)[1]
Dosage:5 and 10 mg/kg
Administration:IP; for 7 days, and after OA-injection continued IP for 7 days
Result:Led to a substantial improvement of the conventional reference spatial memory and cognitive abilities of rats.
分子量

460.44

Formula

C25H20N2O7

CAS 号

2175953-98-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.