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Alexidine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Alexidine图片
CAS NO:22573-93-9
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Alexidine 是一种双双胍,对多种真菌病原体具有抗真菌 (antifungal) 和抗生物膜活性。Alexidine 还具有一种抗肿瘤活性,靶向哺乳动物细胞中的线粒体酪氨酸磷酸酶PTPMT1,并导致线粒体凋亡 (apoptosis)。
生物活性

Alexidine, a bis-biguanide, exhibitsantifungaland antibiofilm activity against a diverse range offungalpathogens. Alexidine is an anticancer agent that targets a mitochondrial tyrosinephosphatase,PTPMT1, in mammalian cells and causes mitochondrialapoptosis[1].

体外研究
(In Vitro)

Alexidine (10 μM, 24 hours) treatment can decimate the biofilm community[1].
Alexidine (0-60 μg/ml, 24 hours) treatment can kill HUVECs and lung A549 cells[1].

Cell Viability Assay[1]

Cell Line:C. albicans,C. auris,A. fumigatus
Concentration:10 μM
Incubation Time:24 hours
Result:Could significantly kill 80% of mature biofilm community.

Cell Viability Assay[1]

Cell Line:HUVECs, lung A549 cells
Concentration:0-60 μg/ml
Incubation Time:24 hours
Result:resulted in 50% killing of HUVECs and lung A549 cells ( CC50>7.37 μg/ml ).
体内研究
(In Vivo)

Alexidine (Jugular vein-catheterized; 48 hours; 3 μg/ml; once) can decimate preformed biofilms growing in the jugular vein catheters of mice[1].

Animal Model:8-week-old C57BL/6 male mice
Dosage:3 μg/ml
Administration:Jugular vein-catheterized, 48 hours, 3 μg/ml, once
Result:Inhibited 67% of fungal biofilm growth and viability, compared to the control untreated biofilms.
分子量

508.79

Formula

C26H56N10

CAS 号

22573-93-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.