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Tumor targeted pro-apoptotic peptide
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CAS NO:1926163-30-5
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Tumor targeted pro-apoptotic peptide (CNGRC-GG-D(KLAKLAK)2) 是一种抗肿瘤肽。Tumor targeted pro-apoptotic peptide 能破坏线粒体膜并促进细胞凋亡，在小鼠中显示出抗癌活性。
生物活性

Tumor targeted pro-apoptotic peptide (CNGRC-GG-D(KLAKLAK)2) is an anti-tumor peptide. Tumor targeted pro-apoptotic peptide disrupts mitochondrial membranes and promotesapoptosis, showing anticancer activity in mice[1].

体外研究
(In Vitro)

Tumor targeted pro-apoptotic peptide (10 μM; 0-20 min) induces mitochondrial swelling in DMECs[1].
Tumor targeted pro-apoptotic peptide (100 μM; 72 h) induces apoptosis in DMECs[1].

Cell Viability Assay[1]

Cell Line:DMECs
Concentration:10 μM
Incubation Time:0-20 min
Result:Induced considerable mitochondrial swelling at a concentration of 10 μM, and mild swelling was evident even at 3 μM.

Apoptosis Analysis[1]

Cell Line:DMECs
Concentration:100 μM
Incubation Time:72 h
Result:Showed the classic morphological indicators of apoptosis, including nuclear condensation and fragmentation.
体内研究
(In Vivo)

Tumor targeted pro-apoptotic peptide inhibits both primary tumor growth and metastasis in mice[1].

Animal Model:Tumor targeted pro-apoptotic peptide (250 μg/mice; tail vein injection; 250 μg a week for 17 weeks) inhibits both primary tumor growth and metastasis in mice[1].
Dosage:250 μg/mice
Administration:Tail vein injection; 250 μg a week for 17 weeks
Result:Exhibited antitumor activity in vivo.
分子量

2168.72

Formula

C94H174N32O22S2

CAS 号

1926163-30-5

Sequence Shortening

CNGRCGGKLAKLAKKLAKLAK-NH2 (Disulfide bridge:Cys1-Cys5)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.