Antitumor agent-70

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Antitumor agent-70

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2454133-88-9

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Antitumor agent-70 (化合物8b) 具有抗肿瘤活性，可以诱导细胞凋亡 (apoptosis)。Antitumor agent-70 抑制多发性骨髓瘤的IC₅₀值为0.12 μM。Antitumor agent-70 是一种潜在的多靶点激酶抑制剂，尤其是对c-Kit。

生物活性

Antitumor agent-70 (compound 8b) has anti-tumor activity and can induce cellapoptosis. Antitumor agent-70 inhibits multiple myeloma with anIC₅₀value of 0.12 μM. Antitumor agent-70 is a potential multi-targeted kinase inhibitor especially forc-Kit^[1].

体外研究
(In Vitro)

Antitumor agent-70 (compound 8b) (0-50 μM, 24 hours) has excellent anti-tumor proliferative activity, especially against multiple myeloma cell RPMI8226^[1].
Antitumor agent-70 (compound 8b) (0-0.2 μM, 24 hours) arrests the cell cycle in G0/G1 phase^[1].
Antitumor agent-70 (compound 8b) (0-0.2 μM, 24 hours) can induce apoptosis to inhibit cell proliferation by promoting ROS release cells^[1].

Cell Proliferation Assay^[1]

Cell Line:	Human myeloma cell line U266, Human multiple myeloma cell line RPMI8226, Human umbilical vein endothelial cells HUVEC
Concentration:	0-50 μM
Incubation Time:	24 hours
Result:	Showed anti-proliferative activity against U266, RPMI8226, HUVEC with an IC₅₀value of 3.81 μM, 0.12 μM, 12.09 μM respectively.

Cell Cycle Analysis^[1]

Cell Line:	RPMI8226
Concentration:	0-0.2 μM
Incubation Time:	24 hours
Result:	Showed a significant increase in the proportion of G0/G1 phase cells while S phase and G2/M phase decreased significantly.

Apoptosis Analysis^[1]

Cell Line:	RPMI8226
Concentration:	0-0.2 μM
Incubation Time:	24 hours
Result:	Induced apoptosis rate increased with increasing concentration. Early apoptosis rate is higher than late apoptosis rate.

分子量

358.39

Formula

C₂₁H₁₈N₄O₂

CAS 号

2454133-88-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.