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Ledipasvir hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ledipasvir hydrochloride图片
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
GS-5885 hydrochloride
产品介绍
Ledipasvir (GS-5885) hydrochloride 是一种有效的HCV NS5A抑制剂,能够抑制 GT1a 和 GT1b 复制子,EC50值分别为 34 pM 和 4 pM。Ledipasvir hydrochloride 也是SARS-CoV 3CLpro的抑制剂,IC50为 1.62 μM。
生物活性

Ledipasvir (GS-5885) hydrochloride is an inhibitor of thehepatitis C virus NS5A, withEC50s of 34 pM and 4 pM against genotype 1a and 1b replicon, respectively. Ledipasvir hydrochloride is also aSARS-CoV3CLproinhibitor with anIC50of 1.62 μM[3].

IC50& Target

EC50: 34 pM (GT1a), 4 pM (GT1b)[1]
IC50: 1.62 Μm (SARS-CoV 3CLpro)[3]

体外研究
(In Vitro)

Ledipasvir hydrochloride has GT1a and 1b EC50values of 31 and 4 pM, respectively, and protein-adjusted EC50values of 210 pM (GT1a) and 27 pM (GT1b) and the intrinsic EC50of 39 is 310 fM for GT1a and 40 fM for GT1b. Ledipasvir hydrochloride is highly protein-bound both in human serum and in the cell-culture medium (containing 10% BSA) of the replicon assay[1]. Ledipasvir hydrochloride exhibits an EC50value of 141 nM against the JFH/3a-NS5A replicon[2].

体内研究
(In Vivo)

Ledipasvir hydrochloride is remarkable not only on the basis of its high replicon potency but also on the basis of its low clearance, good bioavailability, and long half-lives in rat, dog, and monkey and low predicted clearance in human. The pharmacokinetics of Ledipasvir hydrochloride is measured in rats and dogs. Ledipasvir shows good half-lives (rat 1.83 hr, dog 2.63 hr) in plasma, low systemic clearance (CL), and moderate volumes of distribution (Vss) that are greater than total body water volume[1].

Clinical Trial
分子量

925.46

Formula

C49H55ClF2N8O6

中文名称

盐酸雷迪帕韦;盐酸来地帕韦

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.