您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Dimethindene maleate
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Dimethindene maleate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dimethindene maleate图片
CAS NO:3614-69-5
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
200mg电议
500mg电议

产品介绍
Dimethindene maleate 是一种选择性的histamine H1拮抗剂,具有抗组胺效应。Dimethindene maleate 可用于过敏性反应的研究。
生物活性

Dimethindene maleate is a selectivehistamine H1antagonist with antihistamine effects. Dimethindene maleate can be used for the research of hypersensitivity reactions[1][2][3].

IC50& Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Dimethindene maleate (1-1000 μM) suppresses the cromakalim-induced/glibenclamide-sensitive Kcurrents in a concentration-dependent and reversible manner with an IC50value of 29.5 μM[2].
Dimethindene maleate (1-1000 μM) inhibits Y-26763-induced glibenclamide-sensitive Kcurrents with an IC50value of 49 μM[2].

体内研究
(In Vivo)

Dimethindene maleate (0.25 mg; i.p. once) affects wound healing in mice[1].

Animal Model:C57BL/6 mice with wound healing[1]
Dosage:0.25 mg
Administration:Intraperitoneal injection; 0.25 mg once
Result:Significantly delayed skin wound and only showed wound closure impairment in the initial phase wound healing.
分子量

408.49

性状

Solid

Formula

C24H28N2O4

CAS 号

3614-69-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)