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BAY-7081
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BAY-7081图片
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
BAY-7081 是一种有效的、选择性的、具有口服活性的可溶性氰吡啶基PDE9A抑制剂,其IC50为 15 nM。
生物活性

BAY-7081 is a potent, selective, orally active and soluble cyanopyridone-basedPDE9Ainhibitor with anIC50of 15 nM[1].

IC50& Target[1]

PDE9A

15 nM (IC50)

体内研究
(In Vivo)

BAY-7081 (0.3 or 1.0 mg/kg; i.v. or p.o.) 表现出良好的体内药代动力学特性[1]

Animal Model:Wistar rats and dogs[1]
Dosage:0.3 or 1.0 mg/kg
Administration:Intravenous injection or oral (Pharmacokinetic Analysis)
Result:PK Profile of PDE9A Inhibitor BAY-7081 in Selected Speciesa[1]
speciesCLbb[L h–1 kg–1]VSSc[L kg–1]MRTd[h]Fe[%]
Rat2.44.51.961
Dog0.93.04.080

aValues were derived by intravenous (dose 0.3 mg/kg) and oral (dose 1.0 mg/kg) administration of solutions in either plasma 99% + DMSO 1% (rat iv) or EtOH/PEG400/H2O (dog iv, rat and dog po) vehicles.
bBlood clearance.
cVolume of distribution at steady state.
dMean residence time after iv application.
eOral bioavailability.
分子量

362.90

Formula

C19H27ClN4O

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.