Hydrocortisone 是肾上腺皮质分泌的糖皮质激素。

Hydrocortisone, a glucocorticoid receptor agonist, promotes protein catabolism, gluconeogenesis, capillary wall stability, renal excretion of calcium, and suppresses immune and inflammatory responses. Therapeutic Hydrocortisone is a synthetic or semisynthetic analog of natural hydrocortisone hormone produced by the adrenal glands with primary glucocorticoid and minor mineralocorticoid effects.

在离体豚鼠心脏中,Hydrocortisone对缺血后的氧化应激,灌注压和漏出液形成具有降低作用。在人脑微血管内皮细胞系hCMEC/ D3中,Hydrocortisone防止促炎刺激（TNFα的给药）引起的内皮屏障破坏,这是部分基于occludin水平的维持。Hydrocortisone诱导IL-4处理的B细胞中S mu-Sε缺失开关重组,并支持通过IgG4从IgM到IgE的序列等型转换模型。处理树突细胞后,Hydrocortisone使MHC II类分子,直流特异性标记CD83和共刺激分子CD86表达降低,并使IL-12分泌显著减少。此外,其还抑制IL-4的增加（IFN-γ诱导）,但不影响IL-5。Hydrocortisone减少树突状细胞处T细胞的增殖。Hydrocortisone阻止TNF-α诱导的糖萼严重退化,使冠脉阻力上升,增加血管渗漏和通透性、羟乙基淀粉并引起离体豚鼠心脏肥大细胞脱颗粒。 Hydrocortisone对多配体聚糖-1,硫酸乙酰肝素和乙酰透明质酸的缺血后脱落具有抑制作用,以及抑制驻留肥大细胞组胺的释放。

Cells are plated on top of collagen IV-coated transwell chambers for six-well plates (24 mm diameter, membrane material: polyethylene terephthalate (PET), 0.4 μm pores, pore density 1.6×106?cm2) at densities of 2.5×104?cells cm2?per well. When they have reached confluence at day 5, the different experimental sets of cells are transferred to differentiation medium containing reduced amounts of FCS and treated with TNFα or hydrocortisone as indicated.

50-23-7

C21H30O5

362.466

氢化可的松;Cortisol

DMSO:68 mg/mL (187.6 mM)
Ethanol:22 mg/mL (60.7 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years