Rapanone 是一种具有广泛生物活性的天然苯醌，如抗肿瘤、抗氧化、抗炎、抗菌和抗寄生虫活性。它还是选择性人滑膜PLA2抑制剂，IC50值为 2.6 μM。

Rapanone is a natural benzoquinone that is a potent and selective inhibitor of human synovial PLA2.

In the HepG2, rapanone (20–40 μM) induced a concentration-dependent mitochondrial membrane potential dissipation, ATP depletion, hydrogen peroxide generation and, phosphatidyl serine externalization.Rapanone impairs mitochondrial respiration by inhibiting electron transport chain at Complex III and promotes mitochondrial dysfunction[1].

In mice,rapanone (2.5-10 mg/kg; i.p.) exhibits anti-inflammatory effects in the carrageenan paw oedema model

573-40-0

C19H30O4

322.44

2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone;2,5-Dihydroxy-3-tridecylcyclohexa-2,5-diene-1,4-dione;酸藤子醌;拉帕酮

DMSO:65 mg/ml (201.59 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years