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Phyllanthin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Phyllanthin图片
CAS NO:10351-88-9
包装与价格:
包装价格(元)
5 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
1,1'-[(2S,3S)-2,3-双(甲氧基甲基)-1,4-丁二基]双[3,4-二甲氧基苯]
叶下珠素
产品介绍
Phyllanthin 是 Phyllanthus amarus 的一种主要生物活性木脂素成分,具有显著的抗氧化和保肝活性。

产品描述

Phyllanthin is widely used as hepatoprotective and antigenotoxic and inhibit function of P-gp.

体外活性

The activity of P-gp and MRP2 was determined in the uptake assays by monitoring the intracellular accumulation of their specific substrates (calcein acetoxymethyl ester and 5(6)-carboxy-2',7'-dichlorofluorescein diacetate, respectively) with fluorescence spectroscopy. HypoPhyllanthin and Phyllanthin inhibited P-gp function with comparable potencies, but neither compound affected MRP2 activity. When the lignans were washed out before addition of substrate, the inhibitory action of both compounds against P-gp function was lost. These results suggested the reversibility of the inhibition. Moreover, prolonged exposure of the Caco-2 cells to both lignans (up to 7 days) had no effect on P-gp function[1]

Cas No.

10351-88-9

分子式

C24H34O6

分子量

418.52

别名

1,1'-[(2S,3S)-2,3-双(甲氧基甲基)-1,4-丁二基]双[3,4-二甲氧基苯];叶下珠素

储存和溶解度

DMSO:55 mg/ml (131.42 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years