Nauclefine 是一种植物吲哚生物碱天然产物，可通过 PDE3A-SLFN12 依赖性死亡途径诱导多种癌细胞的凋亡。 Nauclefine 结合 PDE3A 但不抑制 PDE3A 的磷酸二酯酶活性。

Nauclefine is a plant indole alkaloid natural product and induces apoptosis of diverse cancer cells via a PDE3A-SLFN12 dependent death pathway. Nauclefine binds PDE3A but does not inhibit the PDE3A's phosphodiesterase activity.

Nauclefine inhibits tumor xenograft growth in vivo, doing so in a PDE3A- and SLFN12-dependent manner[1].

57103-51-2

C18H13N3O

287.32

Parvine

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years