GX 201 是选择性的 NaV1.7 抑制剂，其对 hNaV1.7 的 IC50 值为<3.2 nM。

GX 201 is a selective NaV1.7 inhibitor, IC50 of< 3.2 nM for hNaV1.7.

GX 201 has a relatively long half-life in mice. GX 201 produces analgesia at a free plasma concentration about 3 times the IC50 for high-affinity channel block. GX 201 inhibits nociceptive responses induced by formalin and inflammatory pain caused by complete Freund’s adjuvant (CFA)[1].

1788071-27-1

C25H27ClF4N2O4S

563.00

GX-201

DMSO:60 mg/mL (106.6 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years