UNC0321 是一种有效的组蛋白甲基转移酶 G9a 抑制剂，在 ECSD 和 CLOT 测定中，Ki 为 63 pM，IC50 分别为 9 nM 和 6 nM。 UNC0321 抑制 GLP，在 ECSD 和 CLOT 试验中 IC50 分别为 15 nM 和 23 nM。

UNC0321 is an effective inhibitor of histone methyltransferase G9a with a Ki of 63 pM and with IC50s 9 nM and 6 nM in ECSD and CLOT assays. UNC0321 inhibits GLP with IC50s of 15 nM and 23 nM in ECSD and CLOT assays.

UNC0321 is inactive against SET7/9, SET8/PreSET7, PRMT3 and JMJD2E[1]. UNC0321 reduces H3K9me2 levels in MDA-MB-231 cells with an IC50 of 11 μM[2].

1238673-32-9

C27H45N7O3

515.69

DMSO:31 mg/mL (60.11 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years