Filibuvir 是 HCV NS5B RNA 依赖性 RNA 聚合酶的选择性非共价抑制剂。 Filibuvir 抑制基因型 1a 和 1b 复制子，EC50 为 59 nM。

Filibuvir is a selective and noncovalent inhibitor of HCV NS5B RNA-dependent RNA polymerase. Filibuvir inhibits genotype 1a and 1b replicons with EC50s of 59 nM.

In Huh7.5 cells, Filibuvir (0.01-10000 nM; 48 h) dose-dependently inhibits the WT 1b replicon with EC50s of ~70 nM. Filibuvir decreases primer extension from PE46 with an IC50 of 73 nM, but has no obvious effect on de novo-initiated RNA synthesis with IC50 of 5 μM[2].

877130-28-4

C29H37N5O3

503.64

PF-00868554

DMSO:9mg/mL (17.9mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years