SCD1 inhibitor-3 是一种安全、有效的、具有口服活性的 SCD1 抑制剂。SCD1 inhibitor-3 可用于肥胖症、二型糖尿病、血脂异常等代谢性疾病，以及皮肤病、痤疮、癌症等的研究。

SCD1 inhibitor-3 is a safe, potent and orally active SCD1 inhibitor. SCD1 inhibitor-3 can be used for the research of metabolic diseases such as obesity, type II diabetes and dyslipidemia, as well as skin diseases, acne and cancer.

SCD1 inhibitor-3 (compound 17a) (5 mg/kg; p.o.; 4 hours) reduces the plasma C16:1/C16:0 triglycerides desaturation index by 54 % [1] . SCD1 inhibitor-3 (2~10 mg/kg; p.o.; 4 hours) makes a dose-responsive reduction of plasma triglycerides desaturation index [1] . Animal Model: Lewis rats [1] Dosage: 5 mg/kg Administration: P.o.; 4 hours Result: Reduced the plasma C16:1/C16:0 triglycerides desaturation index by 54 %. Animal Model: Lewis rats [1] Dosage: 2~10 mg/kg Administration: P.o.; 4 hours Result: A dose-responsive reduction of plasma triglycerides desaturation index[1].

1282606-48-7

C19H16FN7O2

393.37

SCD1 inhibitor 17a;SCD1-IN-3

DMSO:35 mg/mL (89 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years