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Heveaflavone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Heveaflavone图片
CAS NO:23132-13-0
包装:5 mg
市场价:3477元

产品名称
橡胶树双黄酮
产品介绍

产品描述

Heveaflavone has anti-proliferation effects, it shows moderate Topoisomerase I inhibitory activity. It also possesses a good antioxidant activity via its DPPH free radical scavenging.

体外活性

The anti-proliferation effects of four fractions (70% ethanol, petroleum ether, dichloromethane and acetic ether extracts) of S. doederleinii on five human cancer cells were monitored. The dichloromethane and acetic ether extracts showed good cytotoxicities to the studied cancer cell lines, guiding the subsequent separation. Two solvent systems composed of n-hexane:ethyl acetate:methanol:water (1:2:1.5:1.5, v/v) and n-hexane:ethyl acetate:methanol:water (3:2:3:2, v/v) were developed for separation of the active fractions, respectively. Identification of the biflavonoids was performed by EI-MS(n) , (1) H- and (13) C-NMR. Under the optimised conditions, 12.6 mg amentoflavone (91.4%), 6.6 mg robustaflavone (90.4%), 7.5 mg 2'', 3''-dihydro-3', 3'''-biapigenin (98.2%) and 7.3 mg 3', 3'''-binaringenin (90.3%) from acetic ether extract (500 mg) and 6.3 mg Heveaflavone (93.5%) and 5.3 mg 7, 4', 7'', 4'''-tetra-O-methyl-amentoflavone (94.5%) from dichloromethane extract (200 mg) were obtained, respectively. The anti-proliferation effects of the six biflavonoids on the five human cancer cells were further verified[1]

Cas No.

23132-13-0

分子式

C33H24O10

分子量

580.54

别名

橡胶树双黄酮

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years