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Satraplatin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Satraplatin图片
CAS NO:129580-63-8
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
顺式-二氯-反式-二乙酸-氨-环己胺合铂
BMS182751
BMY45594
JM216
沙铂
产品介绍
Satraplatin 是一种烷化剂 ,是一种口服的抗肿瘤铂 (IV) 复合物,具有广泛的抗肿瘤效果。

产品描述

Satraplatin is an orally available antineoplastic platinum(IV) complex.Satraplatin has a favorable toxicity profile and appears to have clinical activity against a variety of malignancies.

体外活性

KB-R cells did not show cross-resistance to satraplatin. The expression status of almost all transporters was upregulated in the KB-R cells. There was no difference in the GSH levels between the KB and KB-R cells. Flow cytometric analysis indicated that with satraplatin the G2/M phase was arrested in the KB-R cells. KB-R cells contain enriched side population cells[1].

细胞实验

CDDP-resistant (KB-R) cells and parental cells (KB) pair were used. Viability was assessed using the MTT and clonogenic assay. Real-time polymerase chain reaction (PCR), glutathione (GSH) assay, and flow cytometric analysis were used for further assessment[1].

Cas No.

129580-63-8

分子式

C10H20Cl2N2O4Pt

分子量

498.26

别名

顺式-二氯-反式-二乙酸-氨-环己胺合铂;BMS182751;BMY45594;JM216;沙铂

储存和溶解度

DMSO:33 mg/mL (65.96 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years