Compound 401 是一种可靶向 mTOR的合成DNA-PK抑制剂，IC50为0.28 μM。

Compound 401 is a synthetic DNA-PK inhibitor (IC50 = 0.28 μM) that also targets mTOR but not PI3K.

Compound 401 shows activity against mTOR (IC50 = 5.3 μM) but not p110α/p85α PI3K (IC50 >100 μM). Treatment of cells with Compound 401 blocks the phosphorylation of sites modified by mTOR-Raptor and mTOR-Rictor complexes (ribosomal protein S6 kinase 1 Thr389 and Akt Ser473, respectively).

168425-64-7

C16H15N3O2

281.315

2-morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one

DMSO:6 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years