Wortmannin是一种PI3K抑制剂，IC50值为 3 nM。它阻断自噬形成，并有效抑制Polo-like kinase 1 (PLK1)和PLK3，IC50值分别为 5.8 和 48 nM。

Wortmannin is the first described PI3K inhibitor with IC50 of 3 nM, with little selectivity within the PI3K family. Also blocks autophagosome formation and potently inhibits DNA-PK/ATM with IC50 of 16 nM and 150 nM.

Mitomycin C, by inducing DNA interstrand crosslinks, physically blocks DNA replication, recombination, and RNA transcription. [1] Mitomycin C potentiates TRAIL-induced apoptosis in HCT116 (p53-/-) colon cancer cells and sensitizes TRAIL-resistant colon cancer cells HT-29 to the cytokine by through JNK-independent upregulation of death receptors. [2] In different human cancer cell lines, such OVCAR-5 (ovary), HT-29 (colon), SK-N-MC (neuroblastoma), HEP-2 (liver), COLO-205 (colon), NIH-OVCAR-3 (ovary) and A-549 (lung) cells, Mitomycin C shows cytotoxic activity. [3]

19545-26-7

C23H24O8

428.437

渥曼青霉素;KY-12420;SL-2052

Ethanol:2.1 mg/mL (5 mM)),with gentle warming
DMSO:21.4 mg/mL (50 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years