Remdesivir是一种核苷类似物，具有抗病毒活性，在 HAE 细胞中，对SARS-CoV和MERS-CoV的EC50值为 74 nM，有潜力用于 2019-nCoV (COVID-19) 研究。

Remdesivir is a nucleoside analogue, with effective antiviral activity( EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells)

GS-5734 inhibits murine hepatitis virus (MHV) with similar 50% effective concentration values (EC50) as SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV).?Passage of WT MHV in the presence of the GS-5734 parent nucleoside selected two mutations in the nsp12 polymerase at residues conserved across all CoVs that conferred up to 5.6-fold resistance to GS-5734, as determined by EC50[1].

1809249-37-3

C27H35N6O8P

602.585

GS-5734;瑞德西韦

DMSO:125 mg/mL (207.44 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years