VPC-70063 是 c-Myc-MAX 的抑制剂。 VPC-70063 的 Myc-Max 转录活性抑制率为 106%，IC50 为 8.9 μM，Myc-Max/UBE2C 下游通路抑制率为 94%。 VPC-70063 可用于抗癌研究。

VPC-70063 is an inhibitor of c-Myc-MAX. VPC-70063 exhibits Myc-Max transcriptional activity inhibition of 106% with an IC50 of 8.9 μM and Myc-Max/UBE2C downstream pathway inhibition of 94%. VPC-70063 can be used for studies about anticancer.

VPC-70063 (6.25, 12.5, and 25 μM) causes apoptosis of LNCaP cells as indicated by cleavage of PARP. VPC-70063 (0-500 μM) disrupts the interaction of Myc-Max with DNA in a dose-dependent manner[1].

13571-44-3

C16H12F6N2S

378.33

Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years