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Picolinamide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Picolinamide图片
CAS NO:1452-77-3
包装与价格:
包装价格(元)
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
2-Carbamoylpyridine
2-Picolinamide
2-吡啶甲酰胺
2-Pyridinecarboxamide
Picolinoylamide
产品介绍
Picolinamide 被发现是大鼠胰岛细胞核聚 (ADP-核糖) 合成酶的强抑制剂。

产品描述

Picolinamide is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells.

体外活性

In AR-HEK293 cells stably expressing full-length hAR, ODM-201 inhibits human AR (hAR) with IC50 of 26 nM. ODM-201 inhibits VCaP cell proliferation with IC50 of 230 nM, while has no effect on the viability of AR-negative cell lines tested, DU-145 prostate cancer cells and H1581 lung cancer cells. [1]

体内活性

Overnight treatment of rats with picolinamide, administered as a single injection (4 mmol/kg), inhibits Na+/phosphate cotransport by isolated renal brush border membrane vesicles. There is only a small increase (1.5-fold) in renal cortical NAD content after picolinamide treatment[3].

Cas No.

1452-77-3

分子式

C6H6N2O

分子量

122.127

别名

2-Carbamoylpyridine;2-Picolinamide;2-吡啶甲酰胺;2-Pyridinecarboxamide;Picolinoylamide

储存和溶解度

Ethanol:23 mg/mL (188.3 mM)
H2O:22 mg/mL (180.2 mM)
DMSO:23 mg/mL (188.3 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years