您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > EB-47
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
EB-47
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
EB-47图片
CAS NO:366454-36-6
包装与价格:
包装价格(元)
1 mg电议
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议

产品介绍
EB-47 是一种有效的 PARP-1/ARTD-1 选择性抑制剂,IC50 值为 45 nM,对 ARTD5 的IC50 值为 410 nM,表现出温和的药效。EB-47 模拟底物 NAD+,从烟酰胺延伸至腺苷亚区结合。

产品描述

EB-47 mimics the substrate NAD+ and extends from the nicotinamide to the adenosine subsite.EB-47, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM, shows modest potency against ARTD5 with an IC50 value of 410 nM.

体外活性

The inhibitory effect of EB-47 on CdPARP and HsPARP was 0.86 and 1.0uM with IC50 value respectively, and the inhibitory effect on CdPARP was over 50%[1].

体内活性

EB-47 (2 μM; 5 days) decreases the number of embryo implantation sites and blastocysts at day 5.PARP1 participates in the process of embryo implantation[1].

Cas No.

366454-36-6

分子式

C24H27N9O6

分子量

537.53

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years