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L755507
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
L755507图片
CAS NO:159182-43-1
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
25 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
L755507 是一种有效的选择性β3-AR 激动剂,IC50值为 35 nM。

产品描述

L755507 is an effective, selective agonist of β3-AR(IC50=35 nM).

体外活性

L-755,507 displays an excellent activity profile as an extremely potent human β3 adrenergic receptor agonist (β3 EC50 0.43 nM), with >440-fold selectivity over β1 and β2 binding[1]. L755507 causes a robust concentration-dependent increase in cAMP accumulation in CHO-K1 cells expressing human β3-adrenoceptors(pEC50 values of 12.3)[4]. In a recent study employing a high-throughput screen to identify chemicals capable of modulating HR-mediated genome editing, L-755507 is identified that could enhance HR repair by up to ninefold[3].

体内活性

Acute exposure of rhesus monkeys to L-755,507 elicits lipolysis and metabolic rate elevation, and that chronic exposure increases uncoupling protein 1 expression in rhesus brown adipose tissue[2].

Cas No.

159182-43-1

分子式

C30H40N4O6S

分子量

584.73

储存和溶解度

DMSO:58.5 mg/mL (100 mM)
Ethanol:58.5 mg/mL (100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years