KCC-07 是一种甲基-CpG 结合域蛋白 2 (MBD2) 的选择性、强效和脑渗透抑制剂，具有抗癌活性。它阻止 MBD2 与甲基化 DNA 结合并激活脑特异性血管生成抑制剂 1，诱导抗增殖 BAI1/p53/p21 信号传导。

KCC-07 is a selective, potent and brain-penetrant inhibitor of methyl-CpG-binding domain protein 2(MBD2) with anticancer activity. KCC-07 prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1) inducing anti-proliferative BAI1/p53/p21 signaling.

In vitro, KCC-07 treatment Medulloblastomas (MB) cells?clearly inhibited MB cell growth, consistent with induction of anti-proliferative BAI1/p53/p21 signaling

KCC-07?treatment?Medulloblastomas (MB) cells, Concentration with?10 μM and?Incubation Time with?72 hours

315702-75-1

C14H11N3OS

269.32

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years