您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > TH287 hydrochloride
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
TH287 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TH287 hydrochloride图片
CAS NO:1638211-05-8
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议

产品介绍
TH287 hydrochloride 是一种选择性MTH1抑制剂,IC50值为 0.8 nM。它可用于治疗癌症的研究。

产品描述

TH287 is a selective MTH1 inhibitor(IC50 : 0.8 nM). It causees incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts.

体外活性

TH287 as first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1 protein in cells.?Protein co-crystal structures demonstrate that the inhibitors bind in the active site of MTH1.?The inhibitors cause incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts[1].

Cas No.

1638211-05-8

分子式

C11H11Cl3N4

分子量

305.59

储存和溶解度

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years