Choline Fenofibrate 是 Fenofibric acid 的胆碱盐,在胃肠道中释放游离的 Fenofibric acid。Fenofibric acid 是一种合成的苯氧基异丁酸衍生物和具有抗高血脂活性的前药。
产品描述
Choline Fenofibrate is a choline formulation of fenofibrate, a synthetic phenoxy-isobutyric acid derivate and prodrug with antihyperlipidemic activity.
激酶实验
Cells are harvested, washed, and lysed in NP-40 lysis buffer (50 mM Tris-HCl [pH 7.5], 150 mM NaCl, 0.5% NP-40). Total cell protein is quantified using the Bradford assay and 1-mg/mL protein aliquots are made. Ten microliters of total cell protein is mixed with 290 μL of substrate solution (0.1 mg/mL dithiothreitol [DTT], 0.1 mg/mL albumin, and 1 mM alanine-β-naphthylamide). Fluorometric measurements (340 nm excitation, 400 nm emission) are made after 15 and 30 min. The slope of the line between the 15- and 30-min measurements is used to represent aminopeptidase activity. Total cell protein is preincubated with bestatin, amastatin, puromycin, EDTA, and/or ZnCl2 for 20 min before the fluorometric aminopeptidase assay.
Cas No.
856676-23-8
分子式
C22H28ClNO5
分子量
421.91
别名
非诺贝特胆碱;Trilipix;ABT-335
储存和溶解度
DMSO:6.2 mg/mL),Need ultrasonic and warming
Powder: -20°C for 3 years
In solvent: -80°C for 2 years