您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Resveratrol
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Resveratrol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Resveratrol图片
CAS NO:501-36-0
包装与价格:
包装价格(元)
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
白藜芦醇
trans-Resveratrol
SRT 501
产品介绍
Resveratrol是一种多酚类植物抗毒素,具有抗氧化和化学预防活性。 它具有广泛的目标,包括 COX、SIRT、LOC 等。

产品描述

Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum of targets including COX, SIRT, LOC, etc.

体外活性

Resveratrol inhibits cellular events associated with tumor initiation, promotion, and progression. Resveratrol inhibited the hydroperoxidase activity of COX-1 (ED50 = 3.7 μM) [1]. Resveratrol inhibits the activity of COX-1 and COX-2 (IC50s: 1.1 μM and 1.3 μM for COX-1 and COX-2, respectively) [2]. Resveratrol inhibited TPA-induced DNA binding of NF-kB. Moreover, resveratrol reduced the levels of p65/RelA, a functionally active subunit of NF-kB in nuclear fractions prepared from TPA-treated mouse skin. Resveratrol pretreatment significantly inhibited the phosphorylation of p65-(Ser-536) induced by TPA. Resveratrol pretreatment significantly attenuated TPA-induced stimulation of IKKa and IKKb activity [3]. DNA polymerase inhibiting activity of resveratrol was found to occur at 10 μM in an SV40 viral DNA replication assay. Resveratrol inhibits DNA polymerases α and δ (IC50s: 3.3 and 5 μM, respectively) [4].

体内活性

Resveratrol (RSV) treatment significantly upregulated eNOS gene expression and the levels of phosphorylated CREB in the aorta compared with the untreated control mice. Simultaneously, RSV treatment was observed to upregulate PKA activity and cGMP levels and inhibited superoxide generation in the aorta compared with untreated mice. Compared to vehicle-treated mice, chronic RSV treatment resulted in a significant improvement in endothelium-dependent vasorelaxation response to Ach. Treatment with RSV markedly attenuated the area of atherosclerotic lesions [5].

细胞实验

HAECs were treated with RSV in the presence of isobutylmethylxanthine (IBMX). The reaction was stopped by adding ice-cold 6% trichloroacetic acid and the supernatant fractions of the cellular lysates were extracted, dried and acetylated. Cyclic GMP levels were determined by an enzyme immunoassay kit and results standardized by protein levels [5].

动物实验

Eight-week male apoE-/- mice (C57BL/6 background) were used in the study. Mice were housed in photobiologic light-exposure chambers with a 12:12-h light:dark cycle, and eat food ad libitum. Mice were randomly divided into two groups: one group receiving a high cholesterol diet (HCD, 21% fat, 19.5% casein, and 1.5% cholesterol), the other receiving HCD supplemented with RSV (200 mg/100 g diet). All mice were fed for 8 weeks. To identify the potential role of PKA, some mice were treated with PKA specific inhibitor (KT5720, 1.2 mg/kg) via intraperitoneal injection once a day at the last 4 weeks. The animal experiments were conducted according to the institutional guidelines of Guangdong Provincial People's Hospital [5].

Cas No.

501-36-0

分子式

C14H12O3

分子量

228.247

别名

白藜芦醇;trans-Resveratrol;SRT 501

储存和溶解度

H2O:<1 mgml
Ethanol:<1 mgml
DMSO:42 mg/mL (184 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years