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AZ32
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AZ32图片
CAS NO:2288709-96-4
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
AZ32 是一种口服生物利用度和血脑屏障穿透性 ATM 抑制剂,对 ATM 酶的 IC50<6.2 nM,对细胞内 ATM 的 IC50 为 0.31 μM。

产品描述

AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of<6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell.

体外活性

AZ32 is an enhanced blood-brain barrier (BBB)-penetrating ATM inhibitor. AZ32 blocks the DNA damage response and radiosensitized GBM cells in vitro[1].

体内活性

AZ32 has enhanced BBB penetration that is highly efficient in vivo as radiosensitizer in syngeneic and human, orthotopic mouse glioma model compared with AZ31. AZ32 is a specific inhibitor of the ATM kinase that possesses good BBB penetration in mouse. Following a single oral dose of AZ32 (200 mg/kg) in mice, the free-brain concentrations of AZ32 are in excess of the cellular IC50 for approximately 22 hours[1].

Cas No.

2288709-96-4

分子式

C20H16N4O

分子量

328.37

储存和溶解度

DMSO:150 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years