Loxoribine 是一种鸟苷类似物，是一种口服生物可利用的选择性 Toll 样受体 (TLR) 7 激动剂。 具有抗病毒和抗肿瘤活性。它是一种新型的强效免疫刺激剂，具有较广谱的免疫生物学活性。

Loxoribine is a guanosine analog. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist. It has anti-viral and anti-tumor activities.Loxoribine is a potent new immunostimulant with a relatively broad spectrum of immunobiological activities.

loxoribine activates cells of the innate immune system selectively via the Toll-like receptor (TLR) 7/MyD88-dependent signaling pathway[1]. Loxoribine causes maturation of human monocyte-derived dendritic cells DCs and stimulates their Th-1- and Th-17-polarizing capability[2]. Loxoribine (250 μM; 48 hours) stimulates maturation of MoDCs as shown by up-regulation of CD80, CD83, CD40, CD54, and CCR7[2].

In vivo, Loxoribine (2 mg; s.c.or i.v.) activates murine natural killer (NK) cells[3].

121288-39-9

C13H17N5O6

339.3

7-Allyl-8-oxoguanosine;RWJ 21757;洛索立宾

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years