Isofraxidin 是来自刺五加的香豆素成分，抑制MMP-7表达和人肝癌细胞侵袭。它作用于肝癌细胞，抑制ERK1/2磷酸化。它减弱iNOS和COX-2表达，还抑制TLR4/髓样分化蛋白 2 复合物的形成。

1. Isofraxidin protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. 2. Isofraxidin has a protective effect against LPS-induced ALI, and the protective effect of Isofraxidin seems to result from the inhibition of COX-2 protein expression in the lung, which regulates the production of PGE2. 3. Isofraxidin possesses significant analgesic and anti-inflammatory activities that may be mediated through the regulation of pro-inflammatory cytokines, TNF-α and the phosphorylation of p38 and ERK1/2.

486-21-5

C11H10O5

222.19

异嗪皮啶;Phytodolor;6,8-Dimethoxyumbelliferone;异秦皮啶

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.:Soluble
DMSO:40 mg/mL(180 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years