AB-680 是一种选择性可逆的CD73(胞外核苷酸酶) 抑制剂，具有抗肿瘤活性。它对 hCD73 的Ki值为 4.9 pM，对其选择性是对相关胞外核苷酸酶 CD39 的 10000 多倍。

AB-680 is a highly potent, reversible, and selective inhibitor of CD73 (an ectonucleotidase, Ki: 4.9 pM for hCD73) with anti-tumor activity, displays >10,000-fold selectivity over related ectonucleotidases CD39.

AB-680 inhibits soluble hCD73 (IC50: 0.043 nM), also inhibits hCD73 in CHO cells, suppresses CD73 in human, mouse CD8+ T Cells and hPBMC, with IC50s of 0.070, 0.008, 0.66 and 0.011 nM, respectively.

2105904-82-1

C20H24ClFN4O9P2

580.83

DMSO:180 mg/mL (309.91 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years