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Vancomycin hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Vancomycin hydrochloride图片
CAS NO:1404-93-9
包装与价格:
包装价格(元)
200 mg电议
1 g电议
1 mL*10 mM(in DMSO)电议

产品名称
Vancomycin HCl
盐酸万古霉素
产品介绍
Vancomycin hydrochloride是Vancomycin的盐酸盐,是一种支链三环糖基化肽,对大多数生物体具有杀菌活性,对肠球菌具有抑菌作用。

产品描述

Vancomycin Hydrochloride is the hydrochloride salt of vancomycin, a branched tricyclic glycosylated peptide with bactericidal activity against most organisms and bacteriostatic effect on enterococci.

体外活性

Vancomycin is a large glycopeptide compound with a molecular weight of 1450 Da[1]. Vancomycin is a unique glycopeptide that is structurally unrelated to any currently available antibiotic. It also has a unique mode of action inhibiting the second stage of cell wall synthesis of susceptible bacteria. Vancomycin is active against a large number of species of Gram-positive bacteria, such as Staphylococcus aureus, Staph. epidermidis, Str. agalactiae, Str. bovis, Str. mutans, viridans streptococci, enterococci[2].

体内活性

Vancomycin is administered intravenously, with a standard infusion time of at least 1 h, to minimize infusion-related adverse effects. Subjects with normal creatinine clearance, vancomycin has an α-distribution phase of 30 min to 1 h and a β-elimination half-life of 6-12 h. The volume of distribution is 0.4–1 L/kg. The binding of vancomycin to protein ranges from 10% to 50%. Factors that affect the overall activity of vancomycin include its tissue distribution, inoculum size, and protein-binding effects[1]. Vancomycin treatment of infected mice is related to improved clinical, diarrhea, and histopathology scores and survival during treatment[3].

Cas No.

1404-93-9

分子式

C66H76Cl3N9O24

分子量

1485.72

别名

Vancomycin HCl;盐酸万古霉素

储存和溶解度

H2O:33.33 mg/mL (22.43 mM),Need ultrasonic
DMSO:24 mg/mL (16.15 mM),Need ultrasonic and warming
Powder: -20°C for 3 years
In solvent: -80°C for 2 years