LDC7559 通过在晚期阻断中性粒细胞胞外陷阱 (NET)来抑制gasdermin D (GSDMD)。
产品描述
LDC7559 inhibits gasdermin D (GSDMD) by blocking neutrophil extracellular trap (NET) at late stage.
体外活性
LDC7559 (1 and 5 μM) inhibits IL-1β release upon inflammasome activation, and significantly blocks the lethal effect of both human and murine GSDMD NT domains transfected into HEK293T cells[3].
Cas No.
2407782-01-6
分子式
C20H19N3O3
分子量
349.38
储存和溶解度
DMSO:95 mg/mL (271.91 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
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