RO8191 是一种咪唑并萘啶化合物，是干扰素 (IFN) 受体激动剂。它直接与 IFNα/β 受体 2 结合，激活 IFN 刺激的基因表达和JAK/STAT磷酸化。它通过具有干扰素样活性发挥 cccDNA 调节剂作用，并具有抗HBV活性。

RO8191 (CDM-3008), an imidazonaphthyridine compound, is an agonist of interferon (IFN) receptor.

RO8191 strongly suppresses HCV replicon activity at 72 h in a dose-dependent manner. RO8191 reduces levels of the proteins HCV NS3 and NS4A, which are localized mainly in the perinuclear region of the replicon cells[1].

RO8191 significantly induces antiviral genes Oas1b, Mx1, and Pkr in the livers of six-week-old C57BL/6J mice[1].

691868-88-9

C14H5F6N5O

373.218

CDM-3008;RO4948191

DMSO:3 mg/mL (8.04 mM),ultrasonic and warming and heat to 60°C
Powder: -20°C for 3 years
In solvent: -80°C for 2 years