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Mepazine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Mepazine图片
CAS NO:60-89-9
包装与价格:
包装价格(元)
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议

产品名称
甲哌啶嗪
Pecazine
产品介绍
Mepazine 是一种有效的特异性 MALT1 抑制剂。 Mepazine 抑制 GSTMALT1 全长和 GSTMALT1 325-760,IC50 为 0.83 μM 和 0.42 μM。 Mepazine 增强细胞凋亡并影响细胞活力。

产品描述

Mepazine is a potent and selective inhibitor of MALT1. Mepazine inhibits GSTMALT1 full length and GSTMALT1 325-760 with IC50s of 0.83 μM and 0.42 μM. Mepazine enhances apoptosis and affects the cell viability.

体外活性

Mepazine (5, 10, and 20 μM) decreases cell viability in the ABC-DLBCL cells HBL1, OCI-Ly3, U2932, and TMD8, without significantly affecting GCB-DLBCL cells[1].

体内活性

In female NSG mice with a murine DLBCL xenogeneic tumor model, Mepazine (16 mg/kg; i.p.) interferes with the growth and induces apoptosis of ABC-DLBCL cell line OCI-Ly10. Mepazine strongly impairs the expansion of OCI-Ly10 with daily administration[1].

Cas No.

60-89-9

分子式

C19H22N2S

分子量

310.46

别名

甲哌啶嗪;Pecazine

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years