Mequitazine 是一种有效的、非镇静剂和长效组胺 H1 拮抗剂。

Mequitazine is an effective, nonsedative and long-acting histamine H1 antagonist.

Mequitazine is widely studied and used for allergic disorders such as hay fever and urticaria[1]. Mequitazine demonstrates significant bactericidal effects against all the tested clinical isolates including Ps. aeruginosa. Its effect against the Gram-positive isolates is more pronounced [2].

Mequitazine antagonizes the effect of histamine in guinea-pig ileum competitively. Mequitazine at 107 produces a parallel shift of the dose-response curve to acetylcholine in the rat duodenum. Mequitazine at highest concentration shows anticholinergic activity [3]. Mequitazine inhibits contractile responses to KCl, phenylephrine (PE), 5-hydroxytryptamine (5-HT), and Ca2+ in rat aorta [4].

29216-28-2

C20H22N2S

322.47

Primalan;LM-209;美喹他嗪;Metaplexan;Virginan

DMSO:15 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years