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Mitraphylline
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Mitraphylline图片
CAS NO:509-80-8
包装与价格:
包装价格(元)
20 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
帽柱叶碱
帽柱木菲碱
产品介绍
Mitraphylline 是一种绒毛钩藤中主要的五环吲哚类生物碱,可阻碍脂多糖介导的原代人中性粒细胞活化。

产品描述

Mitraphylline has antiproliferative effects on human glioma and neuroblastoma cell lines. It also has anti-inflammatory activity, it inhibits lipopolysaccharide-mediated activation of primary human neutrophils.

体外活性

The alkaloids of Uncaria tomentosa micropropagated plantlets and root cultures were isolated and identified by NMR and mass spectrometry. Plantlets yielded pteropodine (1), isopteropodine (2), Mitraphylline (3), isoMitraphylline (4), uncarine F (5), speciophylline (6), rhynchophylline (7) and isorhynchophylline (8). In plantlets growing under continuous light, tetracyclic alkaloids 7 and 8 decreased from 20 ± 1.8 at 2 months to 2.2 ± 0.33 mg/g dry wt at 6 months, while the pentacyclic alkaloids 1-4 increased from 7.7 ± 1.4 to 15 ± 0.05 mg/g dry wt, supporting their biogenetic conversion. Micropropagated plantlets produced four times more alkaloids (27.6 ± 3.1 mg/g dry wt) than greenhouse plants.

Cas No.

509-80-8

分子式

C21H24N2O4

分子量

368.43

别名

帽柱叶碱;帽柱木菲碱

储存和溶解度

DMSO:6.76 mg/mL (18.35 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years