JR14a 是人补体C3a受体噻吩拮抗剂，可抑制 C3aR 介导的炎症，对人 C3a 受体的选择性高于 C5a 受体。

JR14a is a potent antagonist of human complement C3a receptor.

In vitro, thiophene compounds potently inhibited intracellular Ca2+ release in human macrophages withoutinhibiting the agonist effects in the same concentration range as the related Complement protein C5a[1].

JR14a reduces mast cell degranulation and macrophage infiltration in BR103-induced rat paw edema[1].

2411440-41-8

C25H26Cl2N4O3S

533.47

5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride

DMSO:90 mg/mL (168.71 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years